If this has been done, I apologize in full but this is REALLY wracking my brain as to the possibilities.

"there's something memorable that happened to a character in the comic is happening in the show in our first episode back and it's not the same character" -Robert Kirkman on Season 3 premiere.

With that said, I sincerely believe that he is talking about something that happens within the Prison walls. It has been but verbally stated inmates WILL be in the prison and seeing how the show goes, it looks like they're going to spend the entire premiere fighting their way into the prison. Whether or not they introduce the prisoners by the end or not, we'll see but if I am right then what IS this memorable thing???

Taking into consideration it's from Volume 3, it could be at least two things... a suicide pact or the survivors are attacked by a serial-killing inmate.

What do you think?

I honestly see Beth or Carol being slaughtered by an inmate, given the inmates are introduced before the end of the episode which is unlikely. So once again, I'm stumped.