- "He asked if I can keep the track playing while we wait."
- —Milton Mamet informing Andrea of Michael's final wish[src]
Michael Jr. and Emily likely died after the outbreak based upon the way Milton talked about them, and Michael's reaction after seeing their pictures and hearing their names.
Coleman is first seen bedridden in a room for Milton's experiment with Andrea. Milton proceeds to begin a process to instill a certain procedure into his subconscious. When the procedure ends, Milton explains to Andrea that he is dying of prostate cancer and that Woodbury doesn't have the supplies to treat him, and that they are waiting for him to pass away, so they can carry on the experiment to discover if walkers can still recognize things from the person they once were. This procedure Milton had repeated several times on Coleman in his last days. Once he begins to reanimate, Milton and Andrea restrain him. Milton begins the procedure with no results. Milton refuses to quit and wants to undo the latch on Michael's right arm to show that he can still do the procedure. Milton undoes the restraint, but Coleman attempts to bite him, and Andrea stabs Michael in the head.
- Prostate Cancer (Alive)
Michael was dying from prostate cancer, so he volunteered for Milton's reanimation experiments. While being kept in the Woodbury lab, watched by Milton and Andrea, Michael died from the cancer.
- Andrea (Zombified)
After being unlatched from his restraints, Michael attacked Milton, although Andrea quickly stabbed him in the head with a small knife before Milton was harmed.
This list shows the victims Michael has killed:
- Possibly a few zombies.
Michael and Milton became friends while Milton monitored Michael's condition in "When the Dead Come Knocking". They were very close; this is shown by Milton's reaction when Michael became a zombie, trying to unfasten Michael and risking his own life to see if a part of Michael still existed. After Andrea put him down, Milton was deeply saddened.
- "When the Dead Come Knocking" (No Lines)
- Michael is one of the oldest characters to die in the TV Series, the others being Dale and Hershel.
- Michael was supposed to have lines, but they were cut prior to filming. 
- Michael is one of the few people in The Walking Dead universe to die of natural causes, the others being David Chalmers, David Chambler, Lucille, Patrick, Caleb Subramanian, several unnamed prison survivors, and possibly Larry (as he was killed before whether he was truly alive or not was established).