Before the outbreak, Maybelle was one of the St. Johns' many dairy cows. Some time before the apocalypse began, Maybelle mated with a bull, or possible insemination, and became pregnant. It is possible that she was a prize winning cow because of the medals located inside of the St. John's house and placed around the stall where Maybelle is held.
Maybelle is first mentioned when Brenda tells the group that she is ill. Mark informs Brenda that Katjaa is a veterinarian and may be able to help. She is first encountered when Lee Everett goes into the St. John's barn. Inside, Duck, Clementine, Katjaa, and Andrew St. John are watching over her. Clementine told Lee that Katjaa said that Maybelle might have her baby that night, but the dairy was overrun by walkers that night, leaving Maybelle's fate a mystery. However, she could have escaped the farm, as the door was open, but it is unknown if she successfully delivered her calf.
- Maybelle is the first domestic animal to be seen in the Video Game.
- She is the only domestic animal to be seen that is not a dog.
- Maybelle is the third alive animal to be seen during "Starved For Help", proceeding the first two crows seen earlier on in the episode.