Not much is known about Lucille’s life before the apocalypse except that she was married to Negan, lived together with him in Virginia and was suffering from cancer shortly before the outbreak. Additionally, she was actively being cheated on by Negan. After she died from her cancer and reanimated, Negan couldn't bring himself to kill the walker Lucille which he came to see as his one weakness. Negan evidently dedicated his signature weapon, a wooden baseball bat wrapped in barbed wire, after her.
Negan tells Gabriel Stokes about Lucille, calling her his one, true wife that existed before the outbreak. Negan admits his sins in cheating on Lucille and how he couldn't bring himself to kill her after she reanimated. With tears in his eyes, Negan calls his inability to kill the reanimated Lucille his one weakness.
- Cancer (Alive)
Lucille was suffering from a cancer shortly before the apocalypse and eventually succumbed to it in the beginning of the outbreak. She reanimated and Negan was unable to bring himself to put her down.
- She one of the few known characters in The Walking Dead to have died of natural causes during the apocalypse