Michonne returns to The Prison, and upon finding Tyreese's undead decapitated head, she drives her sword through it, putting down animated Tyreese. She investigates the wreckage of Dale's RV, but finds nothing except a set of footprints leading away from the battle, which she then follows.
Rick and Carl Grimes are holed up in a nearby town. They investigate a local store, but are attacked by a zombie. Rick tries to drive his axe through its head, but is unable to penetrate its skull. Carl shoots the zombie after Rick lures it outside, and Rick asks him for his gun to dispose of another zombie. They hide in a nearby house, and Rick takes a huge dose of antibiotics. Carl finds him unconscious, with his eyes glazed over.
- Even though Rick had his right hand amputated by The Governor in Issue 28, he is seen with both of his hands when he closes the door of the bathroom.
- The Walking Dead #49 Review A new era begins in Robert Kirkman's zombie epic, IGN, Dan Phillips (May 14, 2008).
- Newsrama - #49 free full issue - Entire Issue 49 available to read.