This issue has some extremely violent and graphic moments that may not make it on to the television show.
|Prison: Teenage Suicide Pact · Decapitated Kids Governor: · Michonne Raped · Governor Mutilated · Tyreese's Decapitation · Lori and Baby Shot To DC: Zombie Dream · Children Murder Each Other · Massacre of the Cannibal Hunters Alexandria Safe-Zone: Mother and Son Devoured · Carl Shot in Eye The Saviors: · Glenn Beaten to Death · Mark's Punishment|
The three Saviors that were seen in Issue 99 are complaining about the plan to attack the Alexandria Safe-Zone at dawn. One of them says that he is going to head for an unknown man by the name of Paul, whose group is farthest away.
The Alexandria Safe-Zone citizens are seen praying for their lives. Spencer approaches Andrea while she is keeping watch on top of the wall. Andrea is reluctant to talk to him when he starts to mention her and Rick, possibly thinking he's going to act jealous, but he instead reveals that he's happy for her and Rick.
Michonne and Rick are talking nearby at the van. Rick thanks Michonne for everything, and says they'll have to be on the road by dawn. Rick says goodbye to Glenn, and states that he is happy for him. Rick then begins his shift of standing guard. Negan, with fifty other Saviors, sneak up on the group and subdue a sleepy Rick by surprise.
The Saviors line up the survivors from the van (Rick, Carl, Glenn, Maggie, Sophia, Michonne, and Heath) on their knees before Negan. Negan informs the group that he wants revenge for the dead Saviors that Rick and his people killed. Negan then dictates the terms for the group's survival; everything in the Alexandria Safe Zone now belongs to the Saviors. Negan further states that there is a new world order and that Rick and his people now follow Negan - or die.
Negan then tells Rick that he is going to kill one of the group to show Rick's people that he is in charge. Negan introduces his weapon of choice for the execution: Lucille - a baseball bat wrapped in barbed wire. After a long narrative from Negan about who should be killed with Lucille, Negan randomly picks Glenn as his victim. Maggie panics, as Glenn begs Negan not to kill him. Rick and the others remain silent and watch in horror and cry with bowed heads as Negan smashes Glenn's head in with Lucille. The first blow fractures Glenn's skull and pops out an eye. Everyone cries, looking horrified and angry at Negan. Negan then taunts the still conscious Glenn who reaches out and calls for Maggie. Negan then repeatedly smashes Lucille into Glenn's head, leaving a mass of broken bone, smashed brains, and spattered blood.
Negan informs Rick and his group that the Saviors will be back in one week to collect half of everything in their community. He turns around, leaving the survivors with Glenn's mangled corpse.
- Rick Grimes
- Carl Grimes
- Maggie Greene
- Dr. Eugene Porter
- Fr. Gabriel Stokes
- Spencer Monroe
- Paul (Mentioned)
- The Saviors.
- First appearance of Negan.
- First appearance of Mike.
- First mention of Paul.
- Last appearance of Glenn (Alive).
- The figure on the cover is Negan, wielding "Lucille".
- Glenn is the first character to die in a triple-digit issue.
- Mike is the first character to be named in a triple-digit issue.
- This issue will have the most variant covers of any issue so far, with sixteen  different covers by authors such as Charlie Adlard, Todd McFarlane, Sean Phillips, Marc Silvestri, Bryan Hitch, Frank Quitely, Ryan Ottley, and Matthew Roberts.  For all the variant covers, see Volume 17: Something to Fear Gallery.
- Robert Kirkman stated that "Issue #100 is going to easily be the most gruesome, most violent, disturbing issue of "The Walking Dead" yet." 
- This issue is the largest issue yet, with 30 pages. 
- One of the variant covers shows Rick Grimes standing amongst a landscape of dead bodies which include every prominent character that has died within The Walking Dead Comic Series.
- Image Comics have released a teaser for Issue 100 that states, "Lucille Is Coming", with The Walking Dead logo beneath it. 
- This was a hint to Negan's weapon of choice; his baseball bat with barbed wire around the end.
- The Walking Dead #100 sold out of it’s initial 383,612 issue order, breaking the record for best-selling comic book in initial orders for any publisher since 1997. 
- Since The Walking Dead #100 sold out of its initial issue order, it went to a second printing. The second printing included a new cover featuring Negan with his signature weapon, "Lucille". 
- It was announced that certain retailers are to receive a special "appreciation" cover of The Walking Dead #100 featuring Negan's weapon of choice, "Lucille". The issues are signed by Robert Kirkman and are limited to 500 copies. 
- This Issue marks the end of the longest running relationship in the comics to date (between Issue 10 and this Issue), between Maggie and Glenn.
- ↑ Rich Johnston Is This The Walking Dead #100 15th Cover? Retailers To Receive Appreciation Signed Cover Next Week Bleeding Cool (August 4, 2012)
- ↑ Spencer Perry Details, Cover for The Walking Dead Issue #100 Shock Till You Drop (April 13, 2012.)
- ↑ TJ Dietsch ROBERT KIRKMAN CELEBRATES 100 ISSUES OF "THE WALKING DEAD" Comic Book Reader (May 9, 2012.)
- ↑ TJ Dietsch EXHUMING "THE WALKING DEAD" WITH CHARLIE ADLARD Comic Book Reader (May 30, 2012.)
- ↑ Renee Phillips 'The Walking Dead' comic series: 100th issue cover released, Examiner, (April 12, 2012).
- ↑ Alex Lynch COMICS: The Walking Dead #100 Teases New Character "Lucille". ComicBookMovie.com (June 19, 2012)
- ↑ Ben Silverio 'The Walking Dead' #100 Sells Out Of Initial 383k Order ScienceFiction.com (July 17, 2012)
- ↑ Russ Burlingame The Walking Dead #100 Gets a Second Printing ComicBook.com (July 18, 2012)
- ↑ Russ Burlingame The Walking Dead Heading Back to Press on #100, 101 With Yet More Covers Comicbook.com (August 22, 2012)
- ↑ Rich Johnston Walking Dead #100 Retailer Limited Variant To Feature Lucille Bleeding Cool (August 8, 2012)