Nothing is known about Henry's life before the outbreak.
Henry flees the zombie attack in Cell Block D with other survivors. Later, Henry is seen with Mr. Jacobson and a woman in the cell block, observing the aftermath and removal of the deceased survivors.
Henry can be seen in the prison yard with Glenn Rhee, Maggie Greene, and other survivors, digging graves for the residents killed in the Cell Block D attack. Sometime later, Henry is sent to Cell Block A for quarantine.
Henry is first seen barely alive and receiving medical treatment from Hershel Greene and Glenn. Hershel attaches an intubator on Henry to enhance his breathing and leaves to check on the other sick survivors of the prison. Glenn watches over him and eventually Henry succumbs to the fever. Glenn attempts to revive him, but fails.
Henry reanimates soon after and tries to attack Glenn, but is lured away by Lizzie Samuels. As Lizzie lures him away, she trips and he falls on top of her. Hershel walks by and tosses him over the railing. Later on, Hershel returns to an undead Henry after Glenn is coughing blood. Maggie breaks into the cell block and shoots him, saving her father.
Henry is shown opening the front gate with Carl Grimes as survivors return to the prison in a flashback sequence.
- The flu (Alive)
Henry succumbs to the flu and dies. He later reanimates as a walker.
- Maggie Greene (Zombified)
As Hershel struggles to get the incubator off Henry's mouth, Maggie shoots an undead Henry in the head.
This list shows the victims Henry has killed:
- "30 Days Without An Accident" (No Lines)
- "Infected" (No Lines)
- "Isolation" (No Lines)
- "Internment" (No Lines)
- "A" (Flashback, No Lines)