The 1995 Isuzu NPR is a diesel powered transport truck. It is seen for the first time in "Consumed". Once Daryl and Noah distracted the walkers by setting a dumpster on fire, they found this truck and stole it. Daryl escaped with Noah on the truck towards ending.
In "Crossed" it was later used to take them and their group (Rick, Noah, Sasha and Tyreese) back to Atlanta to rescue Carol and Beth at Grady Memorial Hospital. Daryl abandoned it after got back from Atlanta.